Antofagasta, Chile’s “Pearl of the North,” is a luxurious gateway between the Pacific and the Atacama. Check into oceanfront suites at Enjoy Antofagasta or the slick Geotel, where infinity pools frame fiery sunsets and concierge teams arrange private drivers into the desert. Stroll the coastal promenade toward the iconic stone arch La Portada, booking a yacht charter to spot sea lions beneath dramatic cliffs. For culture, visit Plaza Colón, its clock tower echoing Big Ben, then tour Huanchaca Ruins Museum, a former silver smelter reborn as a design-forward cultural center. Dine on kamáronés al pil-pil and pisco sours with ocean views at Rosario, then reserve a chef’s‑table tasting at the elegant Rooftop Antay. By day, escape to the eerie beauty of La Chimba National Reserve, where guided hikes cross crimson canyons and viewpoints reveal the city glittering against the sea. Arrange a helicopter or 4x4 excursion toward the Atacama’s Moon Valley for champagne at sunset among sculpted dunes. Finish with designer shopping along Avenida Brasil and a massage in your hotel spa, listening to waves roll against the desert shore.